2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-44141
    tert-Butyl 3-(2-iodoethoxy)propanoate 2296723-16-3
    tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932).
    tert-Butyl 3-(2-iodoethoxy)propanoate
  • HY-42640
    Boc-NH-PEG4-CH2COOH 876345-13-0
    Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-CH2COOH
  • HY-140499
    m-PEG9-acid 2576495-35-5 98.0%
    m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG9-acid
  • HY-23408
    Tos-PEG3 77544-68-4 98.0%
    Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
    Tos-PEG3
  • HY-140923
    Biotin-PEG4-amide-Alkyne 1006592-45-5
    Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amide-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG4-amide-Alkyne
  • HY-141264
    Methyltetrazine-PEG4-acid 1802907-91-0 99.66%
    Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG4-acid
  • HY-140492
    Biotin-PEG8-acid 2143964-62-7 99.81%
    Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG8-acid
  • HY-141382
    Bromoacetamido-PEG4-acid 1807518-67-7
    Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bromoacetamido-PEG4-acid
  • HY-141287
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid 2183440-74-4 98.07%
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid
  • HY-140460
    Fmoc-N-PEG7-acid 1863885-74-8 98.52%
    Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG7-acid
  • HY-134682
    Fmoc-NH-PEG5-C2-NH2 2093277-71-3 98.06%
    Fmoc-NH-PEG5-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG5-C2-NH2
  • HY-140018
    Thiol-PEG3-acid 1347750-82-6
    Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG3-acid
  • HY-130542
    Thiol-PEG8-acid 866889-02-3
    Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG8-acid
  • HY-130591
    Propargyl-PEG4-Br 1308299-09-3
    Propargyl-PEG4-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Br is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-Br is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Br
  • HY-140069
    endo-BCN-PEG4-NHS ester 2252422-32-3 99.27%
    endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG4-NHS ester
  • HY-130315
    Br-PEG4-C2-Boc 564476-32-0 98.0%
    Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Br-PEG4-C2-Boc
  • HY-133391
    Azido-PEG3-azide 101187-39-7 98.26%
    Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-azide
  • HY-140189
    Amino-PEG3-CH2COOH 134978-99-7 99.89%
    Amino-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG3-CH2COOH
  • HY-130396
    DBCO-PEG4-C2-acid 1537170-85-6 99.22%
    DBCO-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-C2-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG4-C2-acid
  • HY-W190728
    Bis-PEG4-TFP ester 1446282-42-3 98.01%
    Bis-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG4-TFP ester
PROTAC Linkers Isoform Comparison

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